Infection and Drug Resistance (Aug 2023)

Trends in Antibiotic Resistance Patterns and Burden of Escherichia Coli Infections in Young Children: A Retrospective Cross-Sectional Study in Shenzhen, China from 2014–2018

  • Patil S,
  • Chen H,
  • Chen Y,
  • Dong S,
  • Mai H,
  • Lopes BS,
  • Liu S,
  • Wen F

Journal volume & issue
Vol. Volume 16
pp. 5501 – 5510

Abstract

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Sandip Patil,1,2 Hongyu Chen,3 Yunsheng Chen,3 Shaowei Dong,2 Huirong Mai,1 Bruno Silvester Lopes,4,5 Sixi Liu,1 Feiqiu Wen1,2 1Department of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 2Paediatric Research Institute, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 3Department of Laboratory Medicine, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 4School of Health and Life Sciences, Teesside University, Middlesbrough, UK; 5National Horizons Centre, Teesside University, Darlington, UKCorrespondence: Feiqiu Wen; Sixi Liu, Department of Haematology and Oncology, Shenzhen Children’s Hospital, 7019 Yitian Road, Futian District, Shenzhen, Guangdong Province, People’s Republic of China, Tel +86-755-83009888, Email [email protected]; [email protected]: The emergence of multi-drug resistant ESBL-producing E. coli poses a global health problem. In this study, we aimed to investigate the prevalence of E. coli infections and their antibiotic susceptibility profiles in paediatric clinical cases in Shenzhen, China from Jan 1, 2014, to Jan 30, 2019, while also determining temporal trends, identifying ESBL-producing strains, and recommending potential empirical antibiotic therapy options.Methods: We isolated a total of 4148 E. coli from different specimens from a single paediatric healthcare centre. Additionally, we obtained relevant demographic data from the hospital’s electronic health records. Subsequently, we performed antimicrobial susceptibility testing for 8 classes of antibiotics and assessed ESBL production.Results: Out of the 4148 isolates, 2645 were from males. The highest burden of E. coli was observed in the age group of 0– 1 years, which gradually declined over the five-year study period. Antimicrobial susceptibility results indicated that 82% of E. coli isolates were highly resistant to ampicillin, followed by 52.36% resistant to cefazolin and 47.46% resistant to trimethoprim/sulfamethoxazole. Notably, a high prevalence of ESBL production (49.54%) was observed among the E. coli isolates, with 60% of them displaying a multi-drug resistance phenotype. However, it is worth mentioning that a majority of the isolates remained susceptible to ertapenem and imipenem. Our findings also highlighted a decrease in E. coli infections in Shenzhen, primarily among hospitalized patients in the 0– 1 year age group. However, this decline was accompanied by a considerably high rate of ESBL production and increasing resistance to multiple antibiotics.Conclusion: Our study underscores the urgent need for effective strategies to combat multi-drug resistant ESBL-producing E. coli Infections.Keywords: E. coli infections, antibiotic susceptibilities, young children, MDR

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