POSSIBILITIES OF OVARIAL SUPPRESSION IN HORMONE-DEPENDENT MAMMARY GLAND CANCER

Abstract

Ovarian suppression (OS) is an effective therapy in hormone-sensitive breast cancer. Oophorectomy and ovarian irradiation have historically been used to achieve the goal of ovarian ablation. Luteinizing hormone releasing hormone (LHRH) analogues have largely supplanted surgical and radiation-based approaches because of less side effects and a lower likelihood of permanent amenorrhea, with the potential for restoration of fertility. LHRH analogues goserelin, buserelin, leuprorelin are equally effective. Buserelin is economically attractive.

Keywords

• metastatic breast cancer
• hormone therapy
• ovarian suppression
• ovarian ablation
• oophorectomy
• irradiation of ovaries
• lhrh analogue
• buserelin