LSD1 inhibitors disrupt the GFI1 transcription repressor complex

Abstract

Pharmacologic inhibition of KDM1A (Lysine Demethylase 1A) induces differentiation in certain subtypes of acute myeloid leukemia. Our recent studies reveal this is dependent upon drug-induced disruption of the GFI1 (Growth Factor Independent 1) transcription repressor complex, leading to activation of enhancers distributed close to genes controlling monocytic lineage differentiation.

Keywords

• gfi1
• lsd1
• aml
• epigenetics
• methylation
• acetylation
• leukemia