Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader

Shaolin Liang; Andrew B. Kinghorn; Margaritis Voliotis; Julia K. Prague; Johannes D. Veldhuis; Krasimira Tsaneva-Atanasova; Craig A. McArdle; Raymond H. W. Li; Anthony E. G. Cass; Waljit S. Dhillo; Julian A. Tanner

doi:10.1038/s41467-019-08799-6

Nature Communications (Feb 2019)

Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader

Shaolin Liang,
Andrew B. Kinghorn,
Margaritis Voliotis,
Julia K. Prague,
Johannes D. Veldhuis,
Krasimira Tsaneva-Atanasova,
Craig A. McArdle,
Raymond H. W. Li,
Anthony E. G. Cass,
Waljit S. Dhillo,
Julian A. Tanner

Affiliations

Shaolin Liang: School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
Andrew B. Kinghorn: School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong
Margaritis Voliotis: Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics, and Physical Sciences, University of Exeter
Julia K. Prague: Section of Endocrinology and Investigative Medicine, Imperial College London
Johannes D. Veldhuis: Endocrine Research Unit, Mayo School of Graduate Medical Education, Mayo Clinic
Krasimira Tsaneva-Atanasova: Department of Mathematics and Living Systems Institute, College of Engineering, Mathematics, and Physical Sciences, University of Exeter
Craig A. McArdle: Laboratories for Integrative Neuroscience and Endocrinology, Bristol Medical School, University of Bristol
Raymond H. W. Li: Department of Obstetrics and Gynaecology, LKS Faculty of Medicine, The University of Hong Kong
Anthony E. G. Cass: Department of Chemistry, Imperial College London
Waljit S. Dhillo: Section of Endocrinology and Investigative Medicine, Imperial College London
Julian A. Tanner: School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong

DOI: https://doi.org/10.1038/s41467-019-08799-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

Read online

Assessment of luteinising hormone pulsatility is important in the diagnosis of reproductive disorders. Here the authors develop a DNA aptamer-based electrochemical analysis integrated into a robotic platform for high-throughput and sensitive analysis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal