Biomolecules & Biomedicine (May 2009)

Action of Propranolol in the Reaction of Smooth Musculature of Tracheal Rings Induced with Acetylcholine, Histamine, Serotonin (5-Ht) And Prostaglandin (Pgf2-alfa) in vitro and in vivo

  • Hilmi Islami,
  • Sadi Bexheti,
  • Halil Ahmetaj,
  • Aziz Šukalo,
  • Suzana Manxhuka,
  • Bajram Nuraj,
  • Xhevat Kamberi,
  • Shaip Krasniqi,
  • Hasime Qorraj,
  • Bashkim Kastrati,
  • Mentor Disha

DOI
https://doi.org/10.17305/bjbms.2009.2834
Journal volume & issue
Vol. 9, no. 2

Abstract

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Actions of acetylcholine (ACh), histamines, serotonins (5-HT) and prostaglandins (PGF2-alfa) in concentrations of 10-4, 10-3, 10-1 and 10-1 mol/dm3 were analyzed in vitro conditions in isolated specimens of tracheas of 24 pigs, 7 guinea pigs, and dead persons for different reasons (8), in the presence and without presence of propranolol. Whilst, research regarding actions of aerosolized histamines (10 mg, 1%, 2 min), in the presence and without the presence of aerosolized propranolol (20 mg, 2%, 2 min) was done in vivo in 6 healthy persons. Study results show that propranolol does not emphasize contraction of the airways smooth musculature as induced by ACh, histamine, 5-HT and PGF2-alfa in vitro conditions (p>0,1). Also, in vivo we found a non-significance of tracheal smooth musculature constriction (p>0,1).

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