Nature Communications (Nov 2020)
Heritability of the HIV-1 reservoir size and decay under long-term suppressive ART
- Chenjie Wan,
- Nadine Bachmann,
- Venelin Mitov,
- François Blanquart,
- Susana Posada Céspedes,
- Teja Turk,
- Kathrin Neumann,
- Niko Beerenwinkel,
- Jasmina Bogojeska,
- Jacques Fellay,
- Volker Roth,
- Jürg Böni,
- Matthieu Perreau,
- Thomas Klimkait,
- Sabine Yerly,
- Manuel Battegay,
- Laura Walti,
- Alexandra Calmy,
- Pietro Vernazza,
- Enos Bernasconi,
- Matthias Cavassini,
- Karin J. Metzner,
- Huldrych F. Günthard,
- Roger D. Kouyos,
- the Swiss HIV Cohort Study
Affiliations
- Chenjie Wan
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Nadine Bachmann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Venelin Mitov
- Department of Biosystems Science and Engineering, ETH Zurich
- François Blanquart
- Center for Interdisciplinary Research in Biology, Collège de France
- Susana Posada Céspedes
- Swiss Institute of Bioinformatics
- Teja Turk
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Kathrin Neumann
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Niko Beerenwinkel
- Department of Biosystems Science and Engineering, ETH Zurich
- Jasmina Bogojeska
- IBM Research - Zurich
- Jacques Fellay
- School of Life Sciences, EPFL
- Volker Roth
- Department of Mathematics and Computer Science, University of Basel
- Jürg Böni
- Institute of Medical Virology, University of Zurich
- Matthieu Perreau
- Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, University of Lausanne
- Thomas Klimkait
- Molecular Virology, Department Biomedicine - Petersplatz, University of Basel
- Sabine Yerly
- Laboratory of Virology, Geneva University Hospital
- Manuel Battegay
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel
- Laura Walti
- Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern
- Alexandra Calmy
- Institute of Global Health, University of Geneva
- Pietro Vernazza
- Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital of St. Gallen
- Enos Bernasconi
- Infectious Diseases Service, Regional Hospital
- Matthias Cavassini
- Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois, University of Lausanne
- Karin J. Metzner
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Huldrych F. Günthard
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- Roger D. Kouyos
- Department of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich
- the Swiss HIV Cohort Study
- DOI
- https://doi.org/10.1038/s41467-020-19198-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The HIV reservoir is a major hurdle for a cure of HIV, but the factors determining its size and dynamics remain unclear. Here the authors show in a large cohort of 610 HIV-1 infected individuals, who are on suppressive ART for a median of 5.4 years, that viral genetic factors contribute substantially to the HIV-1 reservoir size.
