A Fast and Simple Method for the Determination of TBA in ¹⁸F-Labeled Radiopharmaceuticals

Abstract

A simple color spot test for determining the presence of residual tetrabutylammonium (TBA) in various 18F-radiopharmaceuticals is described. The test can be performed in less than five minutes. Iodoplatinate-saturated TLC plates are initially spotted with the 18F-radiopharmaceutical to be tested and TBA, then with deionized water or hydrogen peroxide (H2O2) solution, depending on if an antioxidant stabilizer is part of the pharmaceutical matrix. A distinct brown spot is visible at TBA concentrations of 50 µg/mL and up.

Keywords

• tetrabutylammonium
• tba
• pet
• quality control
• spot test
• radiopharmaceuticals
• psma
• fdopa
• fdg
• iodoplatinate