Effect of hypothyroidism on lipid profile in women at Misan City/Iraq

Abstract

Background: Hypothyroidism is a common endocrine disorder resulting from insufficient production of thyroid hormones, which have significant effects on the synthesis, mobilization, and metabolism of lipids. Objective: The present study aimed to measure some hormonal and biochemical parameters in women suffering from hypothyroidism in Misan province. Materials and Methods: This study included 88 women aged 20–35 years. 5–7 ml of blood was drawn, and serum was obtained. Thyroid and lipid profile tests were performed on all women. Results: The values of thyroid-stimulating hormone increased statistically significantly (P < 0.05) in the C (hypothyroidism women) and D (hypothyroidism and infertility women) groups, whereas triiodothyronine and thyroxin results decreased statistically significantly (P < 0.05) in the C (hypothyroidism women) and D (hypothyroidism and infertility women) groups. Triglycerides and very low-density lipoprotein (LDL)-cholesterol increased statistically significantly (P < 0.05) in the B (infertility women) and C (hypothyroidism women) groups compared to A (healthy women) and D (hypothyroidism and infertility women) groups, whereas LDL cholesterol (LDL-C increased statistically significantly (P < 0.05) in C (hypothyroidism women) and D (hypothyroidism and infertility women) groups compared with A (healthy women) and B (infertility women) groups. There were no statistically significant differences (P < 0.05) in total cholesterol and high-density lipoprotein-cholesterol among the study groups. Conclusions: Hypothyroidism causes increasing level of LDL. Indeed, it is a common cause of secondary dyslipidemia.

Keywords

• hypothyroidism
• lipid profile
• misan
• women