Communications Medicine (Feb 2022)

BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant

  • Ludwig Knabl,
  • Hye Kyung Lee,
  • Manuel Wieser,
  • Anna Mur,
  • August Zabernigg,
  • Ludwig Knabl,
  • Simon Rauch,
  • Matthias Bock,
  • Jana Schumacher,
  • Norbert Kaiser,
  • Priscilla A. Furth,
  • Lothar Hennighausen

DOI
https://doi.org/10.1038/s43856-022-00083-x
Journal volume & issue
Vol. 2, no. 1
pp. 1 – 10

Abstract

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Knabl and Lee et al. use RNA sequencing to assess the impact of vaccination with BNT162b2 on the peripheral innate immune response of a small cohort of COVID-19 patients infected with the SARS-CoV-2 Beta variant. They show an increased JAK-STAT-mediated immune response in vaccinated patients as compared to unvaccinated ones.