Chemotherapeutic Potential of <i>Carthamus Oxycantha</i> Root Extract as Antidiarrheal and In Vitro Antibacterial Activities
Muhammad Ikram,
Amany Magdy Beshbishy,
Muhammad Kifayatullah,
Adedayo Olukanni,
Muhammad Zahoor,
Muhammad Naeem,
Muhammad Amin,
Masood Shah,
Ahmed S. Abdelaziz,
Riaz Ullah,
Ramzi A. Mothana,
Nasir A. Siddiqui,
Gaber El-Saber Batiha
Affiliations
Muhammad Ikram
Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
Amany Magdy Beshbishy
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
Muhammad Kifayatullah
Department of Pharmacy, Faculty of Life Sciences, Sarhad University of Science and Information Technology, Peshawar KPK 25000, Pakistan
Adedayo Olukanni
Department of Biochemistry, Redeemer’s University, Ede 00176, Osun State, Nigeria
Muhammad Zahoor
Department of Biochemistry, University of Malakand, Chakdara 18800, Pakistan
Muhammad Naeem
Department of Chemistry, Abdul Wali Khan University Mardan, Mardan 23200, Pakistan
Muhammad Amin
Department of Zoology, University of Karachi, Karachi 75270, Pakistan
Masood Shah
Department of Chemistry, University of Malakand, Chakdara 18800, Pakistan
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Ramzi A. Mothana
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Nasir A. Siddiqui
Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Gaber El-Saber Batiha
National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi 2-13, Inada-cho, Obihiro, Hokkaido 080-8555, Japan
Our research work was designed to investigate the curative and preventive effects of Carthamus oxycantha root extract against diarrhea and microorganisms. For the antibacterial experiment, the agar well diffusion method was used against standard bacteria Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, and Salmonella typhi, while for the assessment of antidiarrheal activity, castor oil and the magnesium sulfate-induced diarrhea method was used on albino, laboratory-bred (BALB/c) mice at a dose rate of 200 and 400 mg/kg (body weight, b.w) orally. The methanol extract of C. oxycantha significantly (p C. oxycantha showed concentration-dependent antimicrobial properties against S. aureus followed by S. typhi, E. coli, and P. aeroginosa bacterial strains, with inhibitions ranging from 10.5–15 mm. These findings show significant results that C. oxycantha is effective as an antidiarrheal and antibacterial agent. However, further works are needed to establish its mode of action.
