Nature Communications (Jun 2022)
Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine
- Kevin J. Kramer,
- Erin M. Wilfong,
- Kelsey Voss,
- Sierra M. Barone,
- Andrea R. Shiakolas,
- Nagarajan Raju,
- Caroline E. Roe,
- Naveenchandra Suryadevara,
- Lauren M. Walker,
- Steven C. Wall,
- Ariana Paulo,
- Samuel Schaefer,
- Debolanle Dahunsi,
- Camille S. Westlake,
- James E. Crowe,
- Robert H. Carnahan,
- Jeffrey C. Rathmell,
- Rachel H. Bonami,
- Ivelin S. Georgiev,
- Jonathan M. Irish
Affiliations
- Kevin J. Kramer
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Erin M. Wilfong
- Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center
- Kelsey Voss
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Sierra M. Barone
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Andrea R. Shiakolas
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Nagarajan Raju
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Caroline E. Roe
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Naveenchandra Suryadevara
- Vanderbilt Vaccine Center
- Lauren M. Walker
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Steven C. Wall
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Ariana Paulo
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Samuel Schaefer
- Human Immunology Discovery Initiative of the Vanderbilt Center for Immunobiology
- Debolanle Dahunsi
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Camille S. Westlake
- Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center
- James E. Crowe
- Vanderbilt Vaccine Center
- Robert H. Carnahan
- Vanderbilt Vaccine Center
- Jeffrey C. Rathmell
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Rachel H. Bonami
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Ivelin S. Georgiev
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- Jonathan M. Irish
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center
- DOI
- https://doi.org/10.1038/s41467-022-31142-5
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 20
Abstract
Vaccination against COVID-19 has shown activation of different immune cell types. Here the authors characterise the immune response to the SARS-CoV-2 mRNA vaccine using longitudinal CyTOF single cell approaches to characterise antigen specific B and T-cell responses promoted by this vaccine.
