Nature Communications (Aug 2018)
Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration
- Pabitra K. Sahoo,
- Seung Joon Lee,
- Poonam B. Jaiswal,
- Stefanie Alber,
- Amar N. Kar,
- Sharmina Miller-Randolph,
- Elizabeth E. Taylor,
- Terika Smith,
- Bhagat Singh,
- Tammy Szu-Yu Ho,
- Anatoly Urisman,
- Shreya Chand,
- Edsel A. Pena,
- Alma L. Burlingame,
- Clifford J. Woolf,
- Mike Fainzilber,
- Arthur W. English,
- Jeffery L. Twiss
Affiliations
- Pabitra K. Sahoo
- Department of Biological Sciences, University of South Carolina
- Seung Joon Lee
- Department of Biological Sciences, University of South Carolina
- Poonam B. Jaiswal
- Department of Cell Biology, Emory University College of Medicine
- Stefanie Alber
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Amar N. Kar
- Department of Biological Sciences, University of South Carolina
- Sharmina Miller-Randolph
- Department of Biological Sciences, University of South Carolina
- Elizabeth E. Taylor
- Department of Biological Sciences, University of South Carolina
- Terika Smith
- Department of Biological Sciences, University of South Carolina
- Bhagat Singh
- FM Kirby Neurobiology Center and Boston Children’s Hospital and Harvard Medical School
- Tammy Szu-Yu Ho
- FM Kirby Neurobiology Center and Boston Children’s Hospital and Harvard Medical School
- Anatoly Urisman
- Department of Pharmaceutical Chemistry, University of California San Francisco
- Shreya Chand
- Department of Pharmaceutical Chemistry, University of California San Francisco
- Edsel A. Pena
- Department of Statistics, University of South Carolina
- Alma L. Burlingame
- Department of Pharmaceutical Chemistry, University of California San Francisco
- Clifford J. Woolf
- FM Kirby Neurobiology Center and Boston Children’s Hospital and Harvard Medical School
- Mike Fainzilber
- Department of Biomolecular Sciences, Weizmann Institute of Science
- Arthur W. English
- Department of Cell Biology, Emory University College of Medicine
- Jeffery L. Twiss
- Department of Biological Sciences, University of South Carolina
- DOI
- https://doi.org/10.1038/s41467-018-05647-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
G3BP1 is RasGAP SH3 domain binding protein 1 that interacts with 48S pre-initiation complex when translation is stalled. Here, Twiss and colleagues show that neuronal G3BP1 can negatively regulate axonal mRNA translation, and inhibit axonal regeneration after injury.
