Nature Communications (Dec 2017)
Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state
- Gefei Chen,
- Axel Abelein,
- Harriet E. Nilsson,
- Axel Leppert,
- Yuniesky Andrade-Talavera,
- Simone Tambaro,
- Lovisa Hemmingsson,
- Firoz Roshan,
- Michael Landreh,
- Henrik Biverstål,
- Philip J. B. Koeck,
- Jenny Presto,
- Hans Hebert,
- André Fisahn,
- Jan Johansson
Affiliations
- Gefei Chen
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Axel Abelein
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Harriet E. Nilsson
- Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal institute of Technology
- Axel Leppert
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Yuniesky Andrade-Talavera
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Neuronal Oscillations Lab, Karolinska Institutet
- Simone Tambaro
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Lovisa Hemmingsson
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Firoz Roshan
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Neuronal Oscillations Lab, Karolinska Institutet
- Michael Landreh
- Department of Chemistry, University of Oxford, South Parks Road
- Henrik Biverstål
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Philip J. B. Koeck
- Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal institute of Technology
- Jenny Presto
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- Hans Hebert
- Department of Biosciences and Nutrition, Karolinska Institutet, and School of Technology and Health, KTH Royal institute of Technology
- André Fisahn
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Neuronal Oscillations Lab, Karolinska Institutet
- Jan Johansson
- Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-017-02056-4
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
The BRICHOS domain is a chaperone that can act against amyloid-β peptide fibril formation and non-fibrillar protein aggregation. Here the authors use a multidisciplinary approach and show that the Bri2 BRICHOS domain has qualitatively different chaperone activities depending on its quaternary structure.
