Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Xi Lu; Naga Prathyusha Maturi; Malin Jarvius; Irem Yildirim; Yonglong Dang; Linxuan Zhao; Yuan Xie; E-Jean Tan; Pengwei Xing; Rolf Larsson; Mårten Fryknäs; Lene Uhrbom; Xingqi Chen

doi:10.1038/s41467-022-29912-2

Nature Communications (Apr 2022)

Cell-lineage controlled epigenetic regulation in glioblastoma stem cells determines functionally distinct subgroups and predicts patient survival

Xi Lu,
Naga Prathyusha Maturi,
Malin Jarvius,
Irem Yildirim,
Yonglong Dang,
Linxuan Zhao,
Yuan Xie,
E-Jean Tan,
Pengwei Xing,
Rolf Larsson,
Mårten Fryknäs,
Lene Uhrbom,
Xingqi Chen

Affiliations

Xi Lu: Department of Immunology, Genetics and Pathology, Uppsala University
Naga Prathyusha Maturi: Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory
Malin Jarvius: Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University and Science for Life Laboratory
Irem Yildirim: Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory
Yonglong Dang: Department of Immunology, Genetics and Pathology, Uppsala University
Linxuan Zhao: Department of Immunology, Genetics and Pathology, Uppsala University
Yuan Xie: Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory
E-Jean Tan: Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory
Pengwei Xing: Department of Immunology, Genetics and Pathology, Uppsala University
Rolf Larsson: Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University and Science for Life Laboratory
Mårten Fryknäs: Department of Medical Sciences, Cancer Pharmacology and Computational Medicine, Uppsala University and Science for Life Laboratory
Lene Uhrbom: Department of Immunology, Genetics and Pathology, Uppsala University and Science for Life Laboratory, Rudbeck Laboratory
Xingqi Chen: Department of Immunology, Genetics and Pathology, Uppsala University

DOI: https://doi.org/10.1038/s41467-022-29912-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The epigenetic regulation of glioblastoma stem cell (GSC) function remains poorly understood. Here, the authors compare the chromatin accessibility landscape of GSC cultures from mice and patients and suggest that the epigenome of GSCs is cell lineage-regulated and could predict patient survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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