Nature Communications (Feb 2020)

Radical-mediated C-C cleavage of unstrained cycloketones and DFT study for unusual regioselectivity

  • Mingyang Wang,
  • Man Li,
  • Shan Yang,
  • Xiao-Song Xue,
  • Xinxin Wu,
  • Chen Zhu

DOI
https://doi.org/10.1038/s41467-020-14435-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 7

Abstract

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C-C bond scission of unstrained cycloketones with high regioselectivity is a challenging synthetic task. Here, the authors show a facile C-C cleavage of cyclohexanones and cyclopentanones with unusual selectivity under mild conditions with the aid of an in situ formed side-chain aryl radical.