Cancer Management and Research (Oct 2020)
Tobacco Smoke Plays an Important Role in Initiation and Development of Lung Cancer by Promoting the Characteristics of Cancer Stem Cells
Abstract
Ling Lu,1,* Qiaoyan Liang,2,* Shiyue Shen,3 Lei Feng,3 Longtao Jin,1 Zhao feng Liang3 1Women and Children Health Hospital of Zhenjiang, Zhenjiang, Jiangsu 212001, People’s Republic of China; 2People’s Liberation Army Navy No. 971 Hospital, Qingdao, Shandong 266000, People’s Republic of China; 3Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, People’s Republic of China*These authors contributed equally to this workCorrespondence: Longtao JinWomen and Children Health Hospital of Zhenjiang, 20 Zhengdong Road, Zhenjiang, Jiangsu 212001, People’s Republic of ChinaEmail [email protected] feng LiangJiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, Jiangsu 212013, People’s Republic of ChinaEmail [email protected]: Lung cancer is one of the most common causes of cancer-related deaths worldwide. Tobacco smoke is the single greatest risk factor of lung cancer. Although enormous progress in understanding the molecular mechanisms by which tobacco smoke leading to lung cancer has been made, the molecular pathogenesis remains largely unclear. Cancer stem cells have been implicated in cancer initiation, development, and drug resistance. In this review, we reviewed the relationship between tobacco smoke and lung cancer, the key role of cancer stem cells in lung cancer and other tumors. More importantly, we elucidate the mechanism of tobacco smoke promoting lung cancer from the perspective of the characteristics of cancer stem cells induced by tobacco smoke.Keywords: lung cancer, tobacco smoke, cancer stem cells, mechanism
