Scientific Reports (Nov 2022)

A multi-marker integrative analysis reveals benefits and risks of bariatric surgery

  • Simonetta Palleschi,
  • Valeria Guglielmi,
  • Lorenza Nisticò,
  • Carla Ferreri,
  • Claudio Tabolacci,
  • Francesco Facchiano,
  • Egidio Iorio,
  • Alessandro Giuliani,
  • Sonia Brescianini,
  • Emanuela Medda,
  • Corrado Fagnani,
  • Barbara Rossi,
  • Anna Minoprio,
  • Mattea Chirico,
  • Maria Elena Pisanu,
  • Federica Di Nolfo,
  • Paola Fortini,
  • Valeria Simonelli,
  • Sara Baccarini,
  • Serena Laterza,
  • Tiziana Morretti,
  • Ambra Dell’Orso,
  • Federico Manganello,
  • Paolo Gentileschi,
  • Paolo Sbraccia,
  • Eugenia Dogliotti

DOI
https://doi.org/10.1038/s41598-022-23241-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 11

Abstract

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Abstract Bariatric surgery (BS) is an effective intervention for severe obesity and associated comorbidities. Although several studies have addressed the clinical and metabolic effects of BS, an integrative analysis of the complex body response to surgery is still lacking. We conducted a longitudinal data study with 36 patients with severe obesity who were tested before, 6 and 12 months after restrictive BS for more than one hundred blood biomarkers, including clinical, oxidative stress and metabolic markers, peptide mediators and red blood cell membrane lipids. By using a synthetic data-driven modeling based on principal component and correlation analyses, we provided evidence that, besides the early, well-known glucose metabolism- and weight loss-associated beneficial effects of BS, a tardive, weight-independent increase of the hepatic cholesterol metabolism occurs that is associated with potentially detrimental inflammatory and metabolic effects. Canonical correlation analysis indicated that oxidative stress is the most predictive feature of the BS-induced changes of both glucose and lipids metabolism. Our results show the power of multi-level correlation analysis to uncover the network of biological pathways affected by BS. This approach highlighted potential health risks of restrictive BS that are disregarded with the current practice to use weight loss as surrogate of BS success.