Cell‐free DNA analysis for recurrent respiratory papillomatosis: A case report

Satoshi Yamada; Kotaro Kano; Ryuji Ishikawa; Atsushi Imai; Daiki Mochizuki; Kotaro Morita; Kazutaka Takeuchi; Yoshinori Takizawa; Hideya Kawasaki; Kiyoshi Misawa

doi:10.1002/ccr3.9268

Clinical Case Reports (Aug 2024)

Cell‐free DNA analysis for recurrent respiratory papillomatosis: A case report

Satoshi Yamada,
Kotaro Kano,
Ryuji Ishikawa,
Atsushi Imai,
Daiki Mochizuki,
Kotaro Morita,
Kazutaka Takeuchi,
Yoshinori Takizawa,
Hideya Kawasaki,
Kiyoshi Misawa

Affiliations

Satoshi Yamada: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Kotaro Kano: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Ryuji Ishikawa: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Atsushi Imai: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Daiki Mochizuki: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Kotaro Morita: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Kazutaka Takeuchi: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Yoshinori Takizawa: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan
Hideya Kawasaki: Institute for NanoSuit Research, Preeminent Medical Photonics Education and Research Center Hamamatsu University School of Medicine Hamamatsu Japan
Kiyoshi Misawa: Department of Otolaryngology/Head and Neck Surgery Hamamatsu University School of Medicine Hamamatsu Japan

DOI: https://doi.org/10.1002/ccr3.9268
Journal volume & issue: Vol. 12, no. 8
pp. n/a – n/a

Abstract

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Key Clinical Message A 35‐year‐old male presented with recurrent respiratory papillomatosis. Human papillomavirus type 11 was detected from all sites of tumor tissue DNA by PCR. The pre‐surgery cell‐free DNA (cfDNA) viral load (3.33 × 103 copies/ng DNA) fell below the post‐surgical detection limits on achieving remission, suggesting cfDNA's potential as a biomarker.

Published in Clinical Case Reports

ISSN: 2050-0904 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General)
Website: https://onlinelibrary.wiley.com/journal/20500904

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