Nature Communications (Jul 2016)
Wars2 is a determinant of angiogenesis
- Mao Wang,
- Patrick Sips,
- Ester Khin,
- Maxime Rotival,
- Ximing Sun,
- Rizwan Ahmed,
- Anissa Anindya Widjaja,
- Sebastian Schafer,
- Permeen Yusoff,
- Pervinder Kaur Choksi,
- Nicole Shi Jie Ko,
- Manvendra K. Singh,
- David Epstein,
- Yuguang Guan,
- Josef Houštěk,
- Tomas Mracek,
- Hana Nuskova,
- Brittney Mikell,
- Jessie Tan,
- Francesco Pesce,
- Frantisek Kolar,
- Leonardo Bottolo,
- Massimiliano Mancini,
- Norbert Hubner,
- Michal Pravenec,
- Enrico Petretto,
- Calum MacRae,
- Stuart A Cook
Affiliations
- Mao Wang
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Patrick Sips
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Ester Khin
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Maxime Rotival
- Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital
- Ximing Sun
- Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital
- Rizwan Ahmed
- Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital
- Anissa Anindya Widjaja
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Sebastian Schafer
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Permeen Yusoff
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Pervinder Kaur Choksi
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Nicole Shi Jie Ko
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Manvendra K. Singh
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- David Epstein
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Yuguang Guan
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Josef Houštěk
- Institute of Physiology, Czech Academy of Sciences.
- Tomas Mracek
- Institute of Physiology, Czech Academy of Sciences.
- Hana Nuskova
- Institute of Physiology, Czech Academy of Sciences.
- Brittney Mikell
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Jessie Tan
- National Heart Centre Singapore
- Francesco Pesce
- National Heart and Lung Institute, Royal Brompton Campus, Imperial College London
- Frantisek Kolar
- Institute of Physiology, Czech Academy of Sciences.
- Leonardo Bottolo
- Department of mathematics, South Kensington Campus, Imperial College London
- Massimiliano Mancini
- Department of Radiological, Oncological and Anatomo-Pathological Sciences, University of Rome
- Norbert Hubner
- Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine (MDC)
- Michal Pravenec
- Institute of Physiology, Czech Academy of Sciences.
- Enrico Petretto
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- Calum MacRae
- Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School
- Stuart A Cook
- Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, National University of Singapore
- DOI
- https://doi.org/10.1038/ncomms12061
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Blood supply to the heart is crucial for cardiac function. Here, the authors show that the mitochondrial tryptophanyl-tRNA synthetase, WARS2, drives blood vessel generation in zebrafish and rats and that inhibition of Wars2 diminishes blood vessel growth both within and outside in the heart, suggesting a new target for manipulating angiogenesis.
