The cattle genome features
Abstract
Boss taurus is not only an important agricultural species, which during the last 8–10 thousand years since domestication served to humanity as a reliable source of milk, meat, skin, and cattle, is a successful object for the study of obesity, gynecological and infectious diseases of man. Cows are successfully used as a model organism in endocrinology, physiology and reproductive biotechnology. Today, in the world, the number of ruminants – large and small cattle, namely – buffaloes, sheep and goats is estimated at around 3.4 billion. About three-fourths of the world's agricultural land produces fodder suitable for the grazing of these ruminants, which have an amazing ability to effectively convert low-quality vegetable fibers, which are often not suitable for human use, into energy-intensive fat, muscle and milk. This biological process has long been used by humanity, which in the process of breeding has created more than 800 breeds of cattle, which is an important world heritage and a unique scientific resource. The B. taurus genome is estimated at 3000 MB, arranged in 29 pairs of acrocentric autosomes and two sex chromosomes. The sequencing of the bovine genome was conducted by a consortium of more than 300 scientists from 25 different countries. The results of the analysis of the genome are presented in the database ncbi. For the first time, it was sequenced by the genome of one inverted cow of the Hereford breed, L1 Dominette. In addition, today's well-known information on the sequence of six species animals, which identified SNP, was the main resource for the HapMap project, which used 34.470 of them in their analyzes, the EST collection and about 10.000 full-screen cDNA sequences. A genomic card of cattle based on high-density bonds is also reported. The World Society has created and actively used databases containing information on the sequence of genomes, genes, proteins, and their polymorphism. Particular attention deserves descriptions of the results of the analysis of single-nucleotide polymorphism, which allows us to analyze the evolutionary history of phylogenetic bonds in the middle of the species and between different species. The analysis of the associated quantitative features of the loci gives the scientific community additional confidence in identifying the polymorphism of genes, which is the basis of animal productivity. The QTL database contains data on 108 040 bovine cattle, which are associated with 579 different quantitative features. With the polymorphism of individual genes, harmful mutations are associated with the genetic load of populations. To date, 519 traits (disorders) have been described, 203 of them are considered by potential models for research on human diseases. A connection was found between the mutations that caused the 145 polymorphisms.
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