Nature Communications (Oct 2018)
Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel
- Marieke W. Veldkamp,
- Guillaume S. C. Geuzebroek,
- Antonius Baartscheer,
- Arie O. Verkerk,
- Cees A. Schumacher,
- Gedeon G. Suarez,
- Wouter R. Berger,
- Simona Casini,
- Shirley C. M. van Amersfoorth,
- Koen T. Scholman,
- Antoine H. G. Driessen,
- Charly N. W. Belterman,
- Antoni C. G. van Ginneken,
- Joris R. de Groot,
- Jacques M. T. de Bakker,
- Carol Ann Remme,
- Bas J. Boukens,
- Ruben Coronel
Affiliations
- Marieke W. Veldkamp
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Guillaume S. C. Geuzebroek
- Department of Cardiothoracic Surgery, RadboudUMC
- Antonius Baartscheer
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Arie O. Verkerk
- Department of Medical Biology, Academic Medical Center Amsterdam
- Cees A. Schumacher
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Gedeon G. Suarez
- Biomedical Sciences VU University Medical Center
- Wouter R. Berger
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Simona Casini
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Shirley C. M. van Amersfoorth
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Koen T. Scholman
- Department of Medical Biology, Academic Medical Center Amsterdam
- Antoine H. G. Driessen
- Department of Cardiothoracic Surgery, Heart Center, Academic Medical Center
- Charly N. W. Belterman
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Antoni C. G. van Ginneken
- Department of Medical Biology, Academic Medical Center Amsterdam
- Joris R. de Groot
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Jacques M. T. de Bakker
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Carol Ann Remme
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- Bas J. Boukens
- Department of Medical Biology, Academic Medical Center Amsterdam
- Ruben Coronel
- Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-06530-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.
