Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

Shi-qi An; Julie Murtagh; Kate B. Twomey; Manoj K. Gupta; Timothy P. O’Sullivan; Rebecca Ingram; Miguel A. Valvano; Ji-liang Tang

doi:10.1038/s41467-019-10271-4

Nature Communications (May 2019)

Modulation of antibiotic sensitivity and biofilm formation in Pseudomonas aeruginosa by interspecies signal analogues

Shi-qi An,
Julie Murtagh,
Kate B. Twomey,
Manoj K. Gupta,
Timothy P. O’Sullivan,
Rebecca Ingram,
Miguel A. Valvano,
Ji-liang Tang

Affiliations

Shi-qi An: National Biofilms Innovation Centers, Biological Sciences, University of Southampton
Julie Murtagh: School of Microbiology, Biosciences Institute, University College Cork
Kate B. Twomey: School of Microbiology, Biosciences Institute, University College Cork
Manoj K. Gupta: School of Chemistry, University College Cork
Timothy P. O’Sullivan: School of Chemistry, University College Cork
Rebecca Ingram: The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University of Belfast
Miguel A. Valvano: The Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University of Belfast
Ji-liang Tang: State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi University

DOI: https://doi.org/10.1038/s41467-019-10271-4
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

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Biofilm formation and antibiotic tolerance are regulated in Pseudomonas aeruginosa by the protein PA1396, which responds to diffusible signal factors (DSFs) produced by other bacteria. Here, An et al. synthesize DSF analogues that modulate PA1396 activity and thus biofilm formation and antibiotic tolerance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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