Asian Journal of Pharmaceutical Sciences (2014-12-01)

Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability

  • Prakash Khadka,
  • Jieun Ro,
  • Hyeongmin Kim,
  • Iksoo Kim,
  • Jeong Tae Kim,
  • Hyunil Kim,
  • Jae Min Cho,
  • Gyiae Yun,
  • Jaehwi Lee

Journal volume & issue
Vol. 9, no. 6
pp. 304 – 316


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Pharmaceutical particle technology is employed to improve poor aqueous solubility of drug compounds that limits in vivo bioavailability owing to their low dissolution rate in the gastrointestinal fluids following oral administration. The particle technology involves several approaches from the conventional size reduction processes to the newer, novel particle technologies that modify the solubility properties of the drugs and produce solid, powdered form of the drugs that are readily soluble in water and can be easily formulated into various dosage forms. This review highlights the solid particle technologies available for improving solubility, dissolution and bioavailability of drugs with poor aqueous solubility.