JACC: Basic to Translational Science (Oct 2016)

Serial Coronary Imaging of Early Atherosclerosis Development in Fast-Food-Fed Diabetic and Nondiabetic Swine

  • Nienke S. van Ditzhuijzen, MSc,
  • Mieke van den Heuvel, MD,
  • Oana Sorop, PhD,
  • Alexia Rossi, MD, PhD,
  • Timothy Veldhof, MSc,
  • Nico Bruining, PhD,
  • Stefan Roest, BSc,
  • Jurgen M.R. Ligthart, RT,
  • Karen Th. Witberg, CCRN,
  • Marcel L. Dijkshoorn, BSc,
  • Koen Nieman, MD, PhD,
  • Monique T. Mulder, PhD,
  • Felix Zijlstra, MD, PhD,
  • Dirk J. Duncker, MD, PhD,
  • Heleen M.M. van Beusekom, PhD,
  • Evelyn Regar, MD, PhD

DOI
https://doi.org/10.1016/j.jacbts.2016.08.006
Journal volume & issue
Vol. 1, no. 6
pp. 449 – 460

Abstract

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Patients with diabetes mellitus (DM) are at increased risk for atherosclerosis-related events compared to non-DM (NDM) patients. With an expected worldwide epidemic of DM, early detection of anatomic and functional coronary atherosclerotic changes is gaining attention. To improve our understanding of early atherosclerosis development, we studied a swine model that gradually developed coronary atherosclerosis. Interestingly, optical coherence tomography, near-infrared spectroscopy (NIRS), vascular function, and histology demonstrated no differences between development of early atherosclerosis in fast-food-fed (FF) DM swine and that in FF-NDM swine. Coronary computed tomography angiography did not detect early atherosclerosis, but optical coherence tomography and near-infrared spectroscopy demonstrated coronary atherosclerosis development in FF-DM and FF-NDM swine.

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