Atom-Economic Synthesis of 4-Pyrones from Diynones and Water
Yan-Li Xu,
Qing-Hu Teng,
Wei Tong,
Heng-Shan Wang,
Ying-Ming Pan,
Xian-Li Ma
Affiliations
Yan-Li Xu
College of Pharmacy, Guilin Medical University, Guilin 541004, China
Qing-Hu Teng
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Wei Tong
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Heng-Shan Wang
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Ying-Ming Pan
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Xian-Li Ma
College of Pharmacy, Guilin Medical University, Guilin 541004, China
Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones.
