Atom-Economic Synthesis of 4-Pyrones from Diynones and Water

Yan-Li Xu; Qing-Hu Teng; Wei Tong; Heng-Shan Wang; Ying-Ming Pan; Xian-Li Ma

doi:10.3390/molecules22010109

Molecules (Jan 2017)

Atom-Economic Synthesis of 4-Pyrones from Diynones and Water

Yan-Li Xu,
Qing-Hu Teng,
Wei Tong,
Heng-Shan Wang,
Ying-Ming Pan,
Xian-Li Ma

Affiliations

Yan-Li Xu: College of Pharmacy, Guilin Medical University, Guilin 541004, China
Qing-Hu Teng: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Wei Tong: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Heng-Shan Wang: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Ying-Ming Pan: State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences of Guangxi Normal University, Guilin 541004, China
Xian-Li Ma: College of Pharmacy, Guilin Medical University, Guilin 541004, China

DOI: https://doi.org/10.3390/molecules22010109
Journal volume & issue: Vol. 22, no. 1
p. 109

Abstract

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Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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