mBio
(Jun 2021)
A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation
Arden Perkins,
Dan A. Tudorica,
Raphael D. Teixeira,
Tilman Schirmer,
Lindsay Zumwalt,
O. Maduka Ogba,
C. Keith Cassidy,
Phillip J. Stansfeld,
Karen Guillemin
Affiliations
Arden Perkins
ORCiD Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
Dan A. Tudorica
Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
Raphael D. Teixeira
Biozentrum, University of Basel, Basel, Switzerland
Tilman Schirmer
Biozentrum, University of Basel, Basel, Switzerland
Lindsay Zumwalt
Department of Chemistry and Biochemistry Program, Schmid College of Science and Technology, Chapman University, Orange, California, USA
O. Maduka Ogba
Department of Chemistry and Biochemistry Program, Schmid College of Science and Technology, Chapman University, Orange, California, USA
C. Keith Cassidy
Department of Biochemistry, University of Oxford, Oxford, United Kingdom
Phillip J. Stansfeld
School of Life Sciences & Department of Chemistry, University of Warwick, Coventry, United Kingdom
Karen Guillemin
Institute of Molecular Biology, University of Oregon, Eugene, Oregon, USA
DOI
https://doi.org/10.1128/mBio.00173-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Immune cells are well equipped to eliminate invading bacteria, and one of their primary tools is the synthesis of bleach, hypochlorous acid (HOCl), the same chemical used as a household disinfectant. In this work, we present findings showing that many host-associated bacteria possess a bleach-sensing protein that allows them to adapt to the presence of this chemical in their environment.
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