Frontiers in Oncology (Apr 2023)
Dissecting the roles and clinical potential of YY1 in the tumor microenvironment
- MengNa Li,
- MengNa Li,
- MengNa Li,
- MengNa Li,
- JianXia Wei,
- JianXia Wei,
- JianXia Wei,
- ChangNing Xue,
- ChangNing Xue,
- ChangNing Xue,
- XiangTing Zhou,
- ShiPeng Chen,
- ShiPeng Chen,
- ShiPeng Chen,
- LeMei Zheng,
- LeMei Zheng,
- LeMei Zheng,
- YuMei Duan,
- YuMei Duan,
- YuMei Duan,
- HongYu Deng,
- HongYu Deng,
- HongYu Deng,
- Wei Xiong,
- Wei Xiong,
- Wei Xiong,
- FaQing Tang,
- GuiYuan Li,
- GuiYuan Li,
- GuiYuan Li,
- Ming Zhou,
- Ming Zhou,
- Ming Zhou,
- Ming Zhou
Affiliations
- MengNa Li
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- MengNa Li
- Cancer Research Institute, Central South University, Changsha, China
- MengNa Li
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- MengNa Li
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- JianXia Wei
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- JianXia Wei
- Cancer Research Institute, Central South University, Changsha, China
- JianXia Wei
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- ChangNing Xue
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- ChangNing Xue
- Cancer Research Institute, Central South University, Changsha, China
- ChangNing Xue
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- XiangTing Zhou
- The First Clinical College of Changsha Medical University, Changsha, China
- ShiPeng Chen
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- ShiPeng Chen
- Cancer Research Institute, Central South University, Changsha, China
- ShiPeng Chen
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- LeMei Zheng
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- LeMei Zheng
- Cancer Research Institute, Central South University, Changsha, China
- LeMei Zheng
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- YuMei Duan
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- YuMei Duan
- Cancer Research Institute, Central South University, Changsha, China
- YuMei Duan
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- HongYu Deng
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- HongYu Deng
- Cancer Research Institute, Central South University, Changsha, China
- HongYu Deng
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- Wei Xiong
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- Wei Xiong
- Cancer Research Institute, Central South University, Changsha, China
- Wei Xiong
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- FaQing Tang
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- GuiYuan Li
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- GuiYuan Li
- Cancer Research Institute, Central South University, Changsha, China
- GuiYuan Li
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- Ming Zhou
- Key Laboratory of Carcinogenesis, National Health Commission, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- Ming Zhou
- Cancer Research Institute, Central South University, Changsha, China
- Ming Zhou
- The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, China
- Ming Zhou
- Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China
- DOI
- https://doi.org/10.3389/fonc.2023.1122110
- Journal volume & issue
-
Vol. 13
Abstract
Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression. The tumor microenvironment (TME) is identified as the “soil” of tumor that has a critical role in both tumor growth and metastasis. Many studies have found that YY1 is closely related to the remodeling and regulation of the TME. Herein, we reviewed the expression pattern of YY1 in tumors and summarized the function and mechanism of YY1 in regulating tumor angiogenesis, immune and metabolism. In addition, we discussed the potential value of YY1 in tumor diagnosis and treatment and provided a novel molecular strategy for the clinical diagnosis and treatment of tumors.
Keywords
