THE ROLE OF SOME INFLAMMATORY CYTOKINES IN THE DEVELOPMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE ON THE BACKGROUND OF OBESITY

Abstract

Systemic inflammation is a common link in the pathogenesis of chronic obstructive pulmonary disease and obesity. During inflammation all cellular elements are activated and secrete cytokines - factors chemotaxis of inflammatory cells or mediators of inflammation. Cytokines induce acute inflammatory response, may have immunopathological effects on cells and tissues, providing consistency, harmony and completeness of the immune response. Of particular interest is foreign and domestic researchers is to study the role of interleukin-26 (IL-26) in the development and maintenance of inflammation in the body in various diseases. IL-26 (AK-155), is a homodimer protein, which belongs to the family of cytokines IL-10. Expressed by T cells, mononuclear cells, natural killer (NK). Biological activity of IL-26 is poorly understood. However, there is evidence that despite the similarity of IL-10, IL-26 does not inhibit production of inflammatory cytokines such as TNF-α, and IL-1 in monocytes or macrophages. In response to invading infectious agent alveolar macrophages produce increased amounts of IL-26. It is believed that in the lung tissue it increases the pool of immune cells and stimulates neutrophils receptor apparatus, causing the latter to focus on bacterial invasion. All the above-mentioned shows that IL-26 is actively involved in the inflammatory process as proinflammatory cytokines. However, the lack of detailed information on the role of an important factor IL-26 in the development of broncho-pulmonary pathology on the background of obesity determines the need for further study of its direct functions.

Keywords

• chronic obstructive pulmonary disease, obesity, systemic inflammation, interleukin-26