Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19

• Matthias H. Busch,
• Sjoerd A.M.E.G. Timmermans,
• Sander M.J. van Kuijk,
• Joop P. Aendekerk,
• Renée Ysermans,
• Daan P.C. van Doorn,
• Judith Potjewijd,
• Marcel C.G. van de Poll,
• Iwan C.C. van der Horst,
• Jan G.M.C. Damoiseaux,
• Henri M.H. Spronk,
• Hugo ten Cate,
• Chris P. Reutelingsperger,
• Magdolna Nagy,
• Pieter van Paassen

Affiliations

Matthias H. Busch

Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Sjoerd A.M.E.G. Timmermans

Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Sander M.J. van Kuijk

Dept. of Clinical Epidemiology and Medical Technology Assessment

Joop P. Aendekerk

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Renée Ysermans

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Daan P.C. van Doorn

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Judith Potjewijd

Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Marcel C.G. van de Poll

Dept. Intensive Care Medicine

Iwan C.C. van der Horst

Dept. Intensive Care Medicine

Jan G.M.C. Damoiseaux

Central Diagnostic Laboratory

Henri M.H. Spronk

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht

Hugo ten Cate

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands; Thrombosis Expertise Center, Maastricht University Medical Center, Maastricht

Chris P. Reutelingsperger

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Magdolna Nagy

Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht

Pieter van Paassen

Dept. Nephrology and Clinical Immunology, Maastricht University Medical Center, Maastricht, the Netherlands; Dept. Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht