Nature Communications (Feb 2017)
Hotspots of aberrant enhancer activity punctuate the colorectal cancer epigenome
- Andrea J. Cohen,
- Alina Saiakhova,
- Olivia Corradin,
- Jennifer M. Luppino,
- Katreya Lovrenert,
- Cynthia F. Bartels,
- James J. Morrow,
- Stephen C. Mack,
- Gursimran Dhillon,
- Lydia Beard,
- Lois Myeroff,
- Matthew F. Kalady,
- Joseph Willis,
- James E. Bradner,
- Ruth A. Keri,
- Nathan A. Berger,
- Shondra M. Pruett-Miller,
- Sanford D. Markowitz,
- Peter C. Scacheri
Affiliations
- Andrea J. Cohen
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Alina Saiakhova
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Olivia Corradin
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Jennifer M. Luppino
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Katreya Lovrenert
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Cynthia F. Bartels
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- James J. Morrow
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Stephen C. Mack
- Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic
- Gursimran Dhillon
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Lydia Beard
- Case Comprehensive Cancer Center, Case Western Reserve University
- Lois Myeroff
- Case Comprehensive Cancer Center, Case Western Reserve University
- Matthew F. Kalady
- Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic
- Joseph Willis
- Department of Pathology, Case Western Reserve University School of Medicine
- James E. Bradner
- Department of Medical Oncology, Dana-Farber Cancer Institute
- Ruth A. Keri
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Nathan A. Berger
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Shondra M. Pruett-Miller
- Department of Genetics, Genome Engineering and iPSC Center, Washington University
- Sanford D. Markowitz
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- Peter C. Scacheri
- Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine
- DOI
- https://doi.org/10.1038/ncomms14400
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
Active enhancers are defined by the presence of post-translational modifications of histones. Here, the authors use these marks to identify enhancers recurrently activated in colorectal cancer and find that these enhancers turn on oncogenes and are associated with known risk loci for developing the disease.
