Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Zafar Iqbal; Zhuogui Lei; Aruna S. Ramkrishnan; Shu Liu; Mahadi Hasan; Mastura Akter; Yuk Yan Lam; Ying Li

doi:10.1038/s42003-022-04405-6

Communications Biology (Jan 2023)

Adrenergic signalling to astrocytes in anterior cingulate cortex contributes to pain-related aversive memory in rats

Zafar Iqbal,
Zhuogui Lei,
Aruna S. Ramkrishnan,
Shu Liu,
Mahadi Hasan,
Mastura Akter,
Yuk Yan Lam,
Ying Li

Affiliations

Zafar Iqbal: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Zhuogui Lei: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Aruna S. Ramkrishnan: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Shu Liu: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Mahadi Hasan: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Mastura Akter: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Yuk Yan Lam: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong
Ying Li: Department of Neuroscience, College of Veterinary Medicine and Life Sciences, City University of Hong Kong

DOI: https://doi.org/10.1038/s42003-022-04405-6
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 19

Abstract

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Chemogenetic and optogenetic profiling in a rat model of acute pain-related unpleasantness suggests that colorectal distention-induced place aversion is mediated by locus coeruleus noradrenergic signalling to astrocytes in anterior cingulate cortex.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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