A nanofluidic knot factory based on compression of single DNA in nanochannels

Susan Amin; Ahmed Khorshid; Lili Zeng; Philip Zimny; Walter Reisner

doi:10.1038/s41467-018-03901-w

Nature Communications (Apr 2018)

A nanofluidic knot factory based on compression of single DNA in nanochannels

Susan Amin,
Ahmed Khorshid,
Lili Zeng,
Philip Zimny,
Walter Reisner

Affiliations

Susan Amin: Department of Physics, McGill University
Ahmed Khorshid: Department of Physics, McGill University
Lili Zeng: Department of Physics, McGill University
Philip Zimny: Department of Biomedical Engineering, McGill University
Walter Reisner: Department of Physics, McGill University

DOI: https://doi.org/10.1038/s41467-018-03901-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 10

Abstract

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Polymer knots are important for a range of biological systems and engineering applications, yet the variables influencing knotting probability are not well understood. Here the authors develop a nanofluidic device that can detect knots and provide a free energy formalism that can quantify knotting probability in their system.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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