Communications Biology (Feb 2022)

Cryo-EM structure of transcription termination factor Rho from Mycobacterium tuberculosis reveals bicyclomycin resistance mechanism

  • Emmanuel Saridakis,
  • Rishi Vishwakarma,
  • Josephine Lai-Kee-Him,
  • Kevin Martin,
  • Isabelle Simon,
  • Martin Cohen-Gonsaud,
  • Franck Coste,
  • Patrick Bron,
  • Emmanuel Margeat,
  • Marc Boudvillain

DOI
https://doi.org/10.1038/s42003-022-03069-6
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 9

Abstract

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Cryo-EM shows that M. tuberculosis Rho-factor adopts an open, ring-shaped hexamer conformation and a steric bulk in the cavity for bicyclomycin binding, which explains resistance to the antibiotic.