Cyclodextrin-Based Natural Deep Eutectic Solvents: Physicochemical Characterization and Application for Green Extraction of Polyphenols from <i>Moringa oleifera</i> Leaves

Abstract

Natural deep eutectic solvents (NADESs) composed of citric acid and glucose or glycerol and glucose, both with and without the addition of β-cyclodextrin (BCD), were developed and characterized through physicochemical analysis. Parameters such as density, pH, water activity, refractive index, electrical conductivity, and polarity were evaluated. Additionally, their thermal and rheological properties were assessed. The presence of BCD did not significantly affect the polarities of the NADESs but decreased the aw and increased the pH and the apparent viscosity. The designed NADESs were used to extract polyphenolic compounds from Moringa oleifera leaves, providing a sustainable alternative to conventional organic solvents. The results showed that NADESs achieved high extraction yields, demonstrating their effectiveness and potential applications in food and pharmaceutical industries. This study highlights the versatility of NADESs and their relevance in green chemistry and sustainable extraction technologies.

Keywords

• NADES
• green extraction
• <i>M. oleifera</i>
• polyphenols