Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies

Zhan Huang; Zhan Huang; Zhan Huang; Yiping Bai; Yiping Bai; Ying Chen; Ying Chen; Ye Chen; Ye Chen; Yuan Jiang; Jun Zhou; Jun Zhou

doi:10.3389/fphar.2024.1367170

Frontiers in Pharmacology (Feb 2024)

Attenuation of intestinal ischemia-reperfusion-injury by anesthetics: a potentially protective effect of anesthetic management in experimental studies

Zhan Huang,
Zhan Huang,
Zhan Huang,
Yiping Bai,
Yiping Bai,
Ying Chen,
Ying Chen,
Ye Chen,
Ye Chen,
Yuan Jiang,
Jun Zhou,
Jun Zhou

Affiliations

Zhan Huang: Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China
Zhan Huang: Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Zhan Huang: Department of Anesthesiology, Dazhou Integrated TCM & Western Medicine Hospital, Dazhou Second People’s Hospital, Dazhou, China
Yiping Bai: Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China
Yiping Bai: Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Ying Chen: Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China
Ying Chen: Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Ye Chen: Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China
Ye Chen: Department of Traditional Chinese Medicine, The Affiliated Hospital, Southwest Medical University, Luzhou, China
Yuan Jiang: Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, China
Jun Zhou: Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China
Jun Zhou: Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, Southwest Medical University, Luzhou, China

DOI: https://doi.org/10.3389/fphar.2024.1367170
Journal volume & issue: Vol. 15

Abstract

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Intestinal ischemia-reperfusion injury (IRI) is a potentially severe clinical syndrome after major surgical procedures. In addition to causing intestinal mucosa injury, intestinal IRI further damages distant organs, causing the severity of the condition in patients. So far, effective therapy for intestinal IRI is still absent, and the survival rate of the patients is low. Previous experimental studies have shown that some anesthetics can alleviate intestinal IRI and protect organs while exerting their pharmacological effects, indicating that reasonable perioperative anesthesia management may provide potential benefits for patients to avoid intestinal IRI. These meaningful findings drive scholars to investigate the mechanism of anesthetics in treating intestinal IRI in-depth to discuss the possible new clinical uses. In the present mini-review, we will introduce the protective effects of different anesthetics in intestinal IRI to help us enrich our knowledge in this area.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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Abstract

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