Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

Wen Zhang; Georgios Voloudakis; Veera M. Rajagopal; Ben Readhead; Joel T. Dudley; Eric E. Schadt; Johan L. M. Björkegren; Yungil Kim; John F. Fullard; Gabriel E. Hoffman; Panos Roussos

doi:10.1038/s41467-019-11874-7

Nature Communications (Aug 2019)

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits

Wen Zhang,
Georgios Voloudakis,
Veera M. Rajagopal,
Ben Readhead,
Joel T. Dudley,
Eric E. Schadt,
Johan L. M. Björkegren,
Yungil Kim,
John F. Fullard,
Gabriel E. Hoffman,
Panos Roussos

Affiliations

Wen Zhang: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Georgios Voloudakis: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Veera M. Rajagopal: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Ben Readhead: Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Joel T. Dudley: Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Eric E. Schadt: Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Johan L. M. Björkegren: Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Yungil Kim: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
John F. Fullard: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai
Gabriel E. Hoffman: Department of Genetics & Genomic Sciences and Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Panos Roussos: Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-019-11874-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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PrediXcan is a widely used gene expression imputation method that links genetic variants to gene expression. Here, the authors develop EpiXcan which leverages epigenetic annotations to inform transcriptomic imputation and further use the obtained gene-trait associations for computational drug repurposing.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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