THE IMPACT OF UTERINE FIBROMATOSIS ON THE ENDOMETRIUM AND FERTILITY

Abstract

Uterine fibroids are the most common benign tumor that can be found in a woman's reproductive system. The uterine fibroid affects millions of women globally each year and we can consider this pathology, without exaggerating, an important public health problem. Our study was carried out prospectively, in 5 years (2015-2019) and enrolled 480 patients selected with uterine fibroid, from a number of 28809 women who were hospitalized during this period in the university clinic of Obstetrics and Gynecology within the „Saint Pantelimon” Emergency Hospital, Bucharest, Romania. Patients were divided into two groups of study: Group A, those with well-defined, single or multiple uterine fibroid and Group B – patients with diffuse uterine fibromatosis. The clinical, histopathological and immunohistochemical study analyzed and monitored over time, by comparison between the two groups, 52 parameters for each patient, starting with the usual epidemiological factors (age, weight, height, body mass index, personal or family medical history, etc.), continuing with those related to fertility and other clinical issues (chronic pain, metrorrhagia, number of births, recurrent miscarriage, etc.), up to intraoperative parameters (duration of surgery, blood loss, pelvic drainage, the need for blood transfusion) and finally, histopathological aspects. We present in this article some of the results of our study, those related to the quality of the endometrium in the fibromatous uterus and the influence that uterine fibroid had on the fertility of our patients.

Keywords

• uterine fibroid
• endometrium in fibromatosis
• fertility
• sterility