Correlations between clinical, laboratory and morphological parameters of endothelial dysfunction and vascular-platelet hemostasis in patients with type 2 diabetes mellitus and hypertension with poor glycemic compensation

Abstract

Aim. Many questions about the relationship between endothelial dysfunction and morphological substrate of hemostasis damage that occur during the progress of type 2 diabetes mellitus and arterial hypertension require clarification and further advance. Methods and results. In 78 patients with poor glycemic compensation associations between endothelial dysfunction, degree of renal function damage, lipidemic profile and morphological changes of vascular-platelet hemostasis were identified using clinical, laboratory, morphological methods and correlational analysis. Conclusion. It has been established that in the poor glycemic control against the background of significant strengthening relationships between indicators of endothelial dysfunction and damaged platelet hemostasis extremely dense correlations of ultrastructural characteristics of platelets with clinical and laboratory signs of nephropathic and dyslipidemic changes are formed.

Keywords

• Type 2 Diabetes Mellitus
• Hypertension
• Hemostasis