Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Matthew N Tran
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Sang Ho Kwon
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United States
Abby Spangler
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Kelsey D Montgomery
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Madhavi Tippani
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Rahul Bharadwaj
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Joel E Kleinman
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United States
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States
Thomas M Hyde
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United States; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, United States
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United States
Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, United States; Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, United States; The Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, United States
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memory. The LC-NE system is also implicated in multiple neurological and neuropsychiatric disorders. Importantly, LC-NE neurons are highly sensitive to degeneration in both Alzheimer’s and Parkinson’s disease. Despite the clinical importance of the brain region and the prominent role of LC-NE neurons in a variety of brain and behavioral functions, a detailed molecular characterization of the LC is lacking. Here, we used a combination of spatially-resolved transcriptomics and single-nucleus RNA-sequencing to characterize the molecular landscape of the LC region and the transcriptomic profile of LC-NE neurons in the human brain. We provide a freely accessible resource of these data in web-accessible and downloadable formats.
