Nature Communications (Jun 2021)
Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
- Xiao-Hui Wang,
- Sha Xu,
- Xiang-Yu Zhou,
- Rui Zhao,
- Yan Lin,
- Jing Cao,
- Wei-Dong Zang,
- Hui Tao,
- Wei Xu,
- Ming-Qing Li,
- Shi-Min Zhao,
- Li-Ping Jin,
- Jian-Yuan Zhao
Affiliations
- Xiao-Hui Wang
- Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
- Sha Xu
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Xiang-Yu Zhou
- Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
- Rui Zhao
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Yan Lin
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Jing Cao
- Department of Anatomy and Neuroscience Research Institute, School of Basic Medical Sciences, Zhengzhou University
- Wei-Dong Zang
- Department of Anatomy and Neuroscience Research Institute, School of Basic Medical Sciences, Zhengzhou University
- Hui Tao
- Second Hospital of Anhui Medical University, Anhui Medical University
- Wei Xu
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Ming-Qing Li
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Shi-Min Zhao
- Institute of Metabolism and Integrative Biology, State Key Lab of Genetic Engineering, School of Life Sciences, Obstetrics & Gynecology Hospital of Fudan University, Key Laboratory of Reproduction Regulation of NPFPC, and Zhongshan Hospital of Fudan University, Fudan University
- Li-Ping Jin
- Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
- Jian-Yuan Zhao
- Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23827-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Abnormal placentation is associated with recurrent spontaneous abortion (RSA) risk. Here the authors report that low embryonic villous succinate level associates with risk of RSA in patients, and increasing succinate levels is sufficient to reduce the incidence rate in a mouse model of spontaneous abortion.
