An electrochemical gram-scale protocol for pyridylation of inert N-heterocycles with cyanopyridines

Abstract

Summary: Here, we present a protocol to decyanopyridate inert N-heterocycles access to N-fused heterocycles via the mechanism of dual proton-coupled electron transfer (PCET). We describe a detailed guide to performing an electrochemical gram-scale protocol for decyanopyridation of inert N-heterocycles. The desired pyridylated quinolone is synthesized in a 5.0 mmol scale with a yield of 76%.The protocol is limited to cyanopyridines.For complete details on the use and execution of this protocol, please refer to Niu et al. (2022). : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.

Keywords

• NMR
• Chemistry