Nature Communications (Nov 2020)
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
- Lintao Song,
- Zhihua Liu,
- Hui-Hui Hu,
- Ying Yang,
- Terytty Yang Li,
- Zhi-Zhong Lin,
- Jing Ye,
- Jianing Chen,
- Xi Huang,
- Dong-Tai Liu,
- Jing Zhou,
- Yiran Shi,
- Hao Zhao,
- Changchuan Xie,
- Lanfen Chen,
- Erwei Song,
- Shu-Yong Lin,
- Sheng-Cai Lin
Affiliations
- Lintao Song
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Zhihua Liu
- Center of Intestinal Barrier and Fecal Microbiota Transplantation, The Fifth Affiliated Hospital of Guangzhou Medical University
- Hui-Hui Hu
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Ying Yang
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Terytty Yang Li
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Zhi-Zhong Lin
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Jing Ye
- Department of Pathology, Xijing Hospital, Fourth Military Medical University
- Jianing Chen
- Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Xi Huang
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Dong-Tai Liu
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Jing Zhou
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Yiran Shi
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Hao Zhao
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Changchuan Xie
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Lanfen Chen
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Erwei Song
- Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Shu-Yong Lin
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- Sheng-Cai Lin
- State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-020-19694-w
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.
