Морфологія (Jan 2012)
Quantitative morphological characteristics of intravascular platelet activity in patients with diabetes mellitus type 2 with arterial hypertension under losartan treatment
Abstract
We have conducted a quantitative morphological evaluation of intravascular platelet activity and platelet aggregates in patients with diabetes mellitus type 2 with arterial hypertension under correction of arterial blood pressure with losartan and with considering of glycaemic control level and microalbuminuria. It is shown that in the patients with diabetes mellitus in a compensation with microalbuminuria observed significant degree violations of intravascular platelet activity, as a result of this is a significant increase in the relative content of bipolar and active forms with decreasing of disk cytes and rising of small platelet aggregates. Inclusion of losartan in the treatment makes it possible to reduce the degree of platelet hemostasis disorders from the 6th month of the treatment. The standard treatment for one year in the patients with diabetes mellitus in a subcompensation or decompensation is accompanied by increasing intravascular platelet activity and the continuing accumulation of small, medium and large platelet aggregates. Losartan usage in these patients limits the reduction of discocytes and formation of giant spherical platelets with pseudopodia and normalizes the contents of the bipolar forms since 6 month from starting treatment and significantly inhibits the formation of platelet aggregates in comparison with the initial level.
