BUB1B and gynecological malignant tumors

Abstract

The BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) maintains a high fidelity of mitotic chromosome segregation by preventing the initiation of anaphase without the attachment of one or more kinetochore to the spindle, and plays a major role in both signal transduction and the stable attachment of kinetochore to microtubules. The dysregulated expression of BUB1B may affect the occurrence of mitosis-induced aneuploidy, chromosome instability and abnormal cell biological function, leading to cell malignant transformation. This review summarizes the role of BUB1B in the occurrence and development of gynecological malignant tumors.

Keywords

• the bub1 mitotic checkpoint serine/threonine kinase b(bub1b)|gynecological malignant tumors|mitosis