International Journal of General Medicine (Aug 2021)

The Association Between Serum Anion Gap and All-Cause Mortality in Disseminated Intravascular Coagulation Patients: A Retrospective Analysis

  • Hu B,
  • Cao J,
  • Hu Y,
  • Qin Z,
  • Wang J

Journal volume & issue
Vol. Volume 14
pp. 4535 – 4544

Abstract

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Bin Hu,1 Jinxia Cao,1 Yangyang Hu,2 Zuoan Qin,3 Jun Wang1 1Department of Hematology, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of China; 2Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People’s Republic of China; 3Department of Cardiovascular Medicine, First People’s Hospital of Changde City, Changde, Hunan, People’s Republic of ChinaCorrespondence: Jun WangDepartment of Hematology, First People’s Hospital of Changde City, 818 Renmin Road, Changde, 415000, Hunan, People’s Republic of ChinaTel +86 736-7788720Email [email protected]: Studies regarding death risk factors of disseminated intravascular coagulation (DIC) patients were limited. Therefore, we conducted this study to investigate whether the serum anion gap (AG) was independently related to all-cause mortality of DIC patients.Methods: We used the data from Medical Information Mart for Intensive Care III version 1.4 (MIMIC-III v1.4). A total of 2,654 DIC patients were included. The main outcomes were in-hospital, 30-day, and 90-day all-cause mortality. The AG was measured upon ICU admission and its association with mortality was evaluated using the Cox proportional-hazards regression model. The generalized additive model and the smooth curve fitting were introduced to examine the non-linear association.Results: After adjusting for potential covariates, the in-hospital, 30-day, and 90-day all-cause mortality were positively correlated with AG. The hazard ratio (HR), confidence intervals (CI), and P were 1.05 (1.04– 1.07) < 0.0001, 1.06 (1.04– 1.07) < 0.0001, and 1.05 (1.03– 1.07) < 0.0001, respectively. We did not find an obvious non-linear relationship between AG and in-hospital, 30-day, and 90-day mortality, which indicated that the association between AG and all-cause mortality of DIC patients was nearly linear.Conclusion: Serum AG is positively related with all-cause mortality in DIC patients.Keywords: anion gap, disseminated intravascular coagulation, all-cause mortality, MIMIC-III, retrospective study

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