Nature Communications (Sep 2016)

Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy

  • Reza Ghasemi,
  • Eric Lazear,
  • Xiaoli Wang,
  • Saeed Arefanian,
  • Alexander Zheleznyak,
  • Beatriz M. Carreno,
  • Ryuji Higashikubo,
  • Andrew E. Gelman,
  • Daniel Kreisel,
  • Daved H. Fremont,
  • Alexander Sasha Krupnick

DOI
https://doi.org/10.1038/ncomms12878
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here, the authors fuse IL-2 with an NKDG2 binding domain, and show that it induces IL-2 signalling selectively in NKG2D+cells, delaying tumour growth in mice without the side effects of conventional IL-2 therapy.