A review of the safety profile, antioxidant, anti-inflammatory, and bronchorelaxant activities of Waltheria indica Linn (Malvaceae): A potential antiasthmatic phytomedicine
Zakaline Yabré,
Rainatou Boly,
Raogo Ouédraogo,
Abdul Gafar Victoir Coulidiaty,
Gaétan D. Somda,
Rasmané Semdé,
Noufou Ouédraogo,
Estelle Noëla Hoho Youl
Affiliations
Zakaline Yabré
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso; Corresponding author.
Rainatou Boly
Research Institute for Health Sciences (IRSS), 03 PO 7047, Ouagadougou, Burkina Faso
Raogo Ouédraogo
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso
Abdul Gafar Victoir Coulidiaty
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso
Gaétan D. Somda
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso
Rasmané Semdé
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso
Noufou Ouédraogo
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso; Research Institute for Health Sciences (IRSS), 03 PO 7047, Ouagadougou, Burkina Faso
Estelle Noëla Hoho Youl
Drug Development Laboratory (LADME), Center for Training, Research and Expertise in Drug Sciences (CEA-CFOREM), Doctoral School of Health and Sciences (ED2S), Joseph KI-ZERBO University, 03 PO 7021, Ouagadougou, Burkina Faso
Introduction: Waltheria indica Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Previous reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and pharmacological properties of Waltheria indica. This report aims to compile the biological and pharmacological activities that highlight the anti-asthmatic properties of Waltheria indica L. (W. indica). Method: Electronic databases, such as PubMed, Scopus, Hinari, SciFinder, Google Scholar, and ScienceDirect, were used to gather data on Watheria indica. Data on the toxicological, anti-inflammatory, antioxidant, and bronchorelaxant effects of W. indica were collected. Results: Twenty-three studies describing the biological and pharmacological activities relevant to assessing the anti-asthmatic properties of W. indica were found. Nine articles investigated the anti-inflammatory effects, and three manuscripts were found to have bronchorelaxant activity. Five publications reported the antioxidant activity of the plant extracts. Research on the extracts revealed a tolerable safety profile in rats and mice with an LD50 ranging from 300 to 5000 mg/kg body weight, depending on the parts of the plant used. Phenolic compounds, particularly flavonoids, alkaloids, and saponins, were found to be responsible for the activities involved in the assessment of anti-asthmatic properties. Conclusion: The results of this review suggest that W. indica could be a valuable resource for the treatment of asthma and other respiratory diseases. However, further chemical and pharmacological investigations are needed to understand its mechanism of action in treating asthma.
