Von Willebrand factor level in patients with atherothrombotic ischemic stroke and cardioembolic ischemic stroke with atrial fibrillation

Abstract

To define the level of von Willebrand factor in plasma of patients with atherothrombotic ischemic stroke and patients with cardioembolic ischemic stroke with atrial fibrillation and to investigate the possible contribution of platelets in the fluctuations of this factor. Ehe study involved 80 patients diagnosed with atherothrombotic ischemic stroke and cardioembolic ischemic stroke with atrial fibrillation. Von Willebrand factor level was determined by ELISA. Platelet activity was assessed using fotooptical aggregometr AR2110 "Solar" (Belarus). Results: levels of von Willebrand factor exceeded the norm by 63% in patients with cardioembolic ischemic stroke and atrial fibrillation, whereas a significant increase in platelet aggregation was detected in patients with atherothrombotic ischemic stroke. Conclusions: our results may indicate that a significant contribution to the elevation of von Willebrand factor level in blood plasma belongs to endothelial cells, dysfunction of which is more pronounced in patients with cardioembolic ischemic stroke with atrial fibrillation.

Keywords

• atherothrombotic ischemic stroke, cardioembolic ischemic stroke with atrial fibrillation, von Willebrand factor, platelets