Genetic analysis of a large Han Chinese family line with schizoaffective psychosis
Liping Zeng,
Ziyun He,
Di Liu,
Kai Li,
Kesheng Gu,
Qi Sun,
Guisen Mei,
Yingxue Zhang,
Shengkai Yan,
Feng Zhang
Affiliations
Liping Zeng
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China; Corresponding author. NO.984 Hospital of the People’s Liberation Army, Beijing, China
Ziyun He
College of Laboratory Medicine, Zunyi Medical University, Zunyi, 563006, China
Di Liu
The 3rd People's Hospital of Heilongjiang Province-Qinhuangdao Branch, Qinhuangdao, 066001,China
Kai Li
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China
Kesheng Gu
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China
Qi Sun
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China
Guisen Mei
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China
Yingxue Zhang
The Clinical Laboratory of No.984 Hospital of the People's Liberation Army, Beijing, 100094, China
Shengkai Yan
College of Laboratory Medicine, Zunyi Medical University, Zunyi, 563006, China
Feng Zhang
College of Laboratory Medicine, Zunyi Medical University, Zunyi, 563006, China; Beijing Institute of Genomics, Chinese Academy of Sciences No. 1 Beichen West Road, Chaoyang District, Beijing, 100800, China; Ori-Gene (ShangDong)Science and Technology Co., Ltd, 261000, China; Corresponding author. College of Laboratory Medicine, Zunyi Medical University, Zunyi, China.
To locate the specific susceptibility genes of a high incidence of schizoaffective disease (SAD) with autonomic dominant inheritance, we recruited a family group from Henan Province with a high incidence of SAD, including 19 individuals sampled from five generations.We used a genome-wide high-density SNP chip to perform genotype detection. The LINKAGE package and MENDEL programs were used for. The two-point and multipoint analyses were calculated by Merlin and SimWalk2 software to obtain the nonparametric linkage (NPL) value, corresponding P value, and parameter linkage limit of detection (LOD) value.Genome-wide linkage analysis yielded a significant linkage signal located on the short arm of chromosome 19. In the dominant genetic model, the LOD of the multipoint parametric analysis was 2.5, and the nonparametric analysis was 19.4 (P < 0.00001). Further haploid genotype analysis localized the candidate region in the 19p13.3–13.2 region, beginning at rs178414 and ending at rs11668751 with a physical length of approximately 4.9 Mb. We believe that the genes responsible for SAD are in this region.
