Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment

Xiao Xiao; Xiao Xiao; Ting Wang; Leijiao Li; Zhongli Zhu; Weina Zhang; Guihua Cui; Guihua Cui; Wenliang Li; Wenliang Li

doi:10.3389/fphar.2019.00110

Frontiers in Pharmacology (Feb 2019)

Co-delivery of Cisplatin(IV) and Capecitabine as an Effective and Non-toxic Cancer Treatment

Xiao Xiao,
Xiao Xiao,
Ting Wang,
Leijiao Li,
Zhongli Zhu,
Weina Zhang,
Guihua Cui,
Guihua Cui,
Wenliang Li,
Wenliang Li

Affiliations

Xiao Xiao: School of Pharmacy, Jilin Medical University, Jilin, China
Xiao Xiao: Center for Biomaterials, Jilin Medical University, Jilin, China
Ting Wang: Department of the Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, China
Leijiao Li: Jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry, School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, China
Zhongli Zhu: Jilin Provincial Science and Technology Innovation Center of Optical Materials and Chemistry, School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun, China
Weina Zhang: Common Subjects Department, Shangqiu Medical College, Henan, China
Guihua Cui: School of Pharmacy, Jilin Medical University, Jilin, China
Guihua Cui: Center for Biomaterials, Jilin Medical University, Jilin, China
Wenliang Li: School of Pharmacy, Jilin Medical University, Jilin, China
Wenliang Li: Center for Biomaterials, Jilin Medical University, Jilin, China

DOI: https://doi.org/10.3389/fphar.2019.00110
Journal volume & issue: Vol. 10

Abstract

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A strategy for preparing composite micelles (CM) containing both cisplatin(IV) [CisPt(IV)] prodrug and capecitabine using a co-assembly method is described in this study. The CM are capable of an effective release of the anticancer drug cisplatin(II) [CisPt(II)] and capecitabine via acid hydrolysis once they are internalized by cancer cells. Moreover, the CM display a synergistic effect in vitro and the combination therapy in the micellar dosage form leads to reduced systemic toxicity and enhanced antitumor efficacy in vivo.

Published in Frontiers in Pharmacology

ISSN: 1663-9812 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: http://journal.frontiersin.org/journals/pharmacology

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